CAR T-Cells: Treatment Overview, Toxicity Management, and Administration Considerations

Recorded On: 11/14/2018

Chimeric antigen receptor (CAR) T-cells are cellular immunotherapies used for the treatment of some malignancies. This adoptive cell therapy represents a new paradigm in cancer treatment, one in which the patient’s own immune system, specifically T-cells, are engineered to treat his or her cancer. CAR T-cell therapy is a complex treatment associated with unique and serious toxicities, making education a necessity for both the patient and the health care provider. This presentation will provide an overview of CAR T-cell therapy, toxicity assessment and management strategies, administration considerations, and patient education needs for the health care provider.  

Learning Outcomes: At the conclusion of this presentation, learners will be able to:
• Describe the mechanism of action for CAR T-cells
• Identify 3 common toxicities associated with CAR T-cells, as well as associated management strategies 
• Verbalize administration considerations for CAR T-cell products

Karen Anderson, MN, RN, AOCNS, BMTCN, CRNI®

Infusion Manager

Karen Anderson, MN, RN, AOCNS, BMTCN, CRNI®, is an infusion manager at the Banner University of Arizona Cancer Center in Tucson, Arizona. Previously, she was the clinical operations manager at the Bezos Family Immunotherapy Clinic at the Seattle Cancer Care Alliance, a clinic dedicated to supporting scientific advances in cellular immunotherapies and affiliated with the Fred Hutchison Cancer Research Center and the University of Washington. Her professional background includes roles in inpatient and ambulatory settings as a staff nurse, research nurse, and an oncology clinical nurse specialist. Ms. Anderson is currently a PhD student in nursing at the University of Arizona. 

Disclosure: Kite Pharma- A Gilead Company; Consultant Fee; COI resolved

CRNI® RUs: This session has been approved for 1 CRNI® recertification unit and meets the non INS Meeting criteria.

Contact Hours: This session has been approved for 1 contact hour

Expiration date for receipt of contact hours: November 14, 2021

To receive contact hours for this educational activity, you are required to attend the entire educational activity and complete the evaluation.



INS is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.



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