Graft-versus-host disease (GvHD) is a severe inflammatory complication that can occur after an allogeneic hematopoietic cell transplant. In GvHD, the donated bone marrow or peripheral blood stem cells react to the recipient’s body as foreign, and the donated cells or bone marrow attack the body, resulting in alloactivation and an inflammatory cytokine release. The activation of inflammatory cytokines can result in alloreactive tissue injury and inflammation. There are 2 forms of GvHD: acute graft-versus-host disease (aGvHD) and chronic graft-versus-host disease (cGvHD). This session will provide an overview of GvHD and discuss both acute and chronic responses.

Learning Outcomes: After the session, attendees will be able to describe both the acute and chronic GvHD response and recognize the potential impact of each response.

Contact Hours: 1
CRNI® RUs: 2