Episode 25: September 12, 2018 - Demystifying Gout (Part 1): Pathophysiology, Population Prevalence, and Dietary Influences

Gout is a relatively common form of inflammatory arthritis that causes periods of painful swelling in joints. Although it is similar in many ways to rheumatoid arthritis, it is not an autoimmune disease, but rather a metabolic disorder. In this, the first of 3 podcasts on demystifying gout, the pathophysiology of gout, population prevalence, and the role diet plays in gouty arthritis will be discussed, and the first segment in a 3-part case study will be introduced.

Vickie Sayles, BSN, RN-BC, CRNI®

Clinical Nurse Manager

Vickie L. Sayles, BSN, RN-BC, CRNI®, is the clinical nurse manager for the department of rheumatic and immunologic diseases at the Cleveland Clinic Foundation in Cleveland, Ohio. She is board-certified in ambulatory nursing, rheumatology nursing, and infusion nursing, and she currently serves as treasurer of the Rheumatology Nurse Society. A presenter at various conferences in the United States, Ms. Sayles has spoken on subjects such as infusion nursing, infusion medications, biologic drugs, and biosimilar drugs.

Vickie L. Sayles, BSN, RN-BC, CRNI®
Clinical Nurse Manager, Department of Rheumatic and Immunologic Disease
Cleveland Clinic Foundation

Gout is a chronic metabolic disease experienced by approximately 4% of the population of the United States. Gout is caused by the buildup of uric acid crystals in the joints, kidneys, and other body systems, and can be debilitating for patients. Early detection of gout results in significantly fewer complications over time and reduces associated comorbidities. This 3-part case study will discuss the clinical signs and symptoms, identify the triggers associated with attacks, examine various treatment options, and review common complications and prevention.


  • Borghi C, Perez-Ruiz F. Urate lowering therapies in the treatment of gout: a systematic review and meta-analysis.  Eur Rev Med Pharmacol Sci. 2016;20(5):983-992. Accessed 18, August 2018.
  • Dalbeth N, Stamp LK, Merriman TR. The genetics of gout: towards personalised medicine? BMC Med. 2017;15(1):108.  doi: 10.1186/s12916-017-0878-5.
  • Shekelle PG, Newberry SJ, Fitzgerald JD, et al. Management of gout:  a systematic review in support of an American College of Physicians Clinical Practice Guideline.  Ann Intern Med. 2017;166(1):37-51.  doi: 10.7326/M16-0461.
  • Wagler V, Pumerantz A. Management of acute and recurrent gout. Ann Intern Med. 2017;166(10):759.  doi: 10.7326/L17-0144.


Demystifying Gout (Part 1)